Cutaneous manifestations of systemic lupus erythematosus
DOI:
https://doi.org/10.63688/f1shbw51Keywords:
Systemic lupus erythematosus, cutaneous manifestations, photosensitivityAbstract
Introduction: Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease that may present with various cutaneous manifestations, some of which may constitute an initial expression of the disease.
Objective: To synthesize the available scientific evidence on the cutaneous manifestations of SLE, considering pathophysiological aspects, the role of photosensitivity, and their main clinical characteristics.
Methods: A narrative literature review was conducted through searches in PubMed, Scopus, SciELO, and Google Scholar. Publications in Spanish and English, available in full text and published between January 2020 and March 2026, were included. Of the 160 documents initially identified, 15 articles met the selection criteria and were included in the analysis.
Results: The reviewed literature identified specific and nonspecific cutaneous manifestations. Specific forms included acute, subacute, and chronic cutaneous lupus, whereas nonspecific manifestations included alopecia, mucosal ulcers, vascular alterations, and Raynaud’s phenomenon. Ultraviolet radiation was identified as a relevant factor in the onset or exacerbation of skin lesions.
Conclusions: Cutaneous manifestations show heterogeneous clinical expression, and their recognition may contribute to the suspicion and comprehensive assessment of SLE. Identification of clinical patterns and triggering factors, particularly photosensitivity, should complement medical evaluation.
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References
Chasis, F., & Teboul, A. (2026). Actualización sobre la patogenia, el diagnóstico y el tratamiento del lupus eritematoso cutáneo. Journal of the European Academy of Dermatology and Venereology, 40, 782–800. https://doi.org/10.1111/jdv.70186
Cosentino, M., Martire, M. V., García, L., & García, M. A. (2023). Manifestaciones cutáneas en pacientes con lupus eritematoso sistémico: formas al inicio de la enfermedad y durante el seguimiento. Análisis retrospectivo. Reumatología Clínica, 19(6), 293–298. https://doi.org/10.1016/j.reuma.2022.11.005
Curtiss, P., Walker, A. M., & Chong, B. F. (2022). A systematic review of the progression of cutaneous lupus to systemic lupus erythematosus. Frontiers in Immunology, 13, 866319. https://doi.org/10.3389/fimmu.2022.866319
Estadt, S. N., Maz, M. P., Musai, J., & Kahlenberg, J. M. (2022). Mechanisms of photosensitivity in autoimmunity. Journal of Investigative Dermatology, 142(3), 849–856. https://doi.org/10.1016/j.jid.2021.05.007
Etchegaray-Morales, I., Mendoza-Pinto, C., Arellano-Avendaño, F. J., Ibañez-Ovando, S., Munguía-Realpozo, P., Orbe-Sosa, J. G., Ramírez-Lara, E., & García-Carrasco, M. (2024). Epidemiology of systemic lupus erythematosus in Latin America. Reumatología Clínica (English Edition), 20(10), 560–566. https://doi.org/10.1016/j.reumae.2024.11.003
Fijałkowska, A., Kądziela, M., & Żebrowska, A. (2024). The spectrum of cutaneous manifestations in lupus erythematosus: A comprehensive review. Journal of Clinical Medicine, 13(8), 2419. https://doi.org/10.3390/jcm13082419
Günther, C., & Wenzel, J. (2023). Lupus erythematosus. Journal der Deutschen Dermatologischen Gesellschaft, 21(4), 426–430. https://doi.org/10.1111/ddg.15049
Heredia, L., Arellano, J., & Corredoira, Y. (2020). Lupus eritematoso asociado a eritema multiforme: Síndrome de Rowell. Reporte del primer caso en Chile. Revista Médica de Chile, 148(11), 1690–1693. https://doi.org/10.4067/S0034-98872020001101690
Jatwani, S., & Hearth Holmes, M. (2024). Lupus eritematoso cutáneo subagudo. National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK554554/
Klein, B., Billi, A. C., Abernathy-Close, L., & Kahlenberg, J. M. (2025). Cutaneous lupus erythematosus—from pathogenesis to targeted therapy. Nature Reviews Rheumatology, 21(12), 703–718. https://doi.org/10.1038/s41584-025-01318-6
Niebel, D., de Vos, L., Fetter, T., Brägelmann, C., & Wenzel, J. (2023). Cutaneous lupus erythematosus: An update on pathogenesis and future therapeutic directions. American Journal of Clinical Dermatology, 24(4), 521–540. https://doi.org/10.1007/s40257-023-00774-8
Stull, C., Sprow, G., & Werth, V. P. (2023). Cutaneous involvement in systemic lupus erythematosus: A review for the rheumatologist. The Journal of Rheumatology, 50(1), 27–35. https://doi.org/10.3899/jrheum.220089
Vale, E. C. S. do, & Garcia, L. C. (2023). Cutaneous lupus erythematosus: A review of etiopathogenic, clinical, diagnostic and therapeutic aspects. Anais Brasileiros de Dermatologia, 98(3), 355–372. https://doi.org/10.1016/j.abd.2022.09.005
Valenzuela, P., Ladino, M., & Vargas, N. (2021). Caracterización de pacientes con lupus eritematoso sistémico infantil y su transición a etapa adulta. Andes Pediatrica, 92(3), 375–381. https://doi.org/10.32641/andespediatr.v92i3.1653
Zeb, R., Chinome, D. V. C., Chacon, M., Singh, T., Chowdary, M. M., Manzanares Vidals, C. J., Mehnaz, S., Torres Medina, A. F., Gadde, P. S., Lingamgunta, R. P. K., Barakat, A., & Rai, M. (2024). Cutaneous manifestations of systemic lupus erythematosus and their correlation with cardiac involvement. Cureus, 16(12), e76478. https://doi.org/10.7759/cureus.76478
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Copyright (c) 2026 Nathalie Xiomara Arreaga Espinoza, Evelyn Yuliana Lara Llanos, Millie Tiffani León Jiménez, Andrés Roberto García Chavarria, Santiago Daniel Muñoz Lara (Autor/a)
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